Publications

For those interested in therapeutic nanoparticles, this review in Norwegian is a useful introduction (the whole issue is about nanoscience, and gives an excellent overview on this field):

Publications related to nanomedicine:

  1. Evensen L, Johansen PL, Koster G, Zhu K, Herfindal L, Speth M, Fam SB, Fenaroli F, Prasmickaite L, Mælandsmo G, Snaar-Jagalska E, Griffiths G (2015). Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale 8(2), 862-77 (doi: 10.1039/c5nr07289a). In this paper, the group of Gareth Griffiths demonstrate how we can use zebrafish embryo to trace nanoparticles in real-time, and also how nanoparticle material and surface modifications influence circulation time and uptake by macrophages.Graphical abstract: Zebrafish as a model system for characterization of nanoparticles against cancer
  2. Sauvage F, Barratt G, Herfindal L, Vergnaud-Gauduchon J (2015):The use of nanocarriers in acute myeloid leukaemia therapy: challenges and current status. Curr Pharm Biotechnol 17(1), 30-41. In this review we discuss how nanocarriers can be used to improve therapy of acute myeloid leukaemia. This non-operable cancer is associated with heavy chemotherapy and poor outcome, but still only a few nano-sized drug formulations are being developed.
  3. Myhren L, Nilssen I, Nicolas V, Døskeland SO, Barrat G, Herfindal L (2014): Multi-functional liposomes containing daunorubicin and emetine against acute myeloid leukemia. Eur J Pharm Biopharm 88(1):186-93. We have developed a liposomal drug formulation, where we have encapsulated the two drugs emetine and daunorubicine in liposomes coated with PEG for “stealth” ability, and folate on the surface to target leukaemia cells. This formulation were particularly efficient against acute myeloid leukaemia in in vitro experiments.Basic RGB
  4. Oftedal L, Myhren L, Jokela J, Gausdal G, Sivonen K, Døskeland SO, Herfindal L# (2012): The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. BBA Biomembranes 1818(12):3000-9. Here, we used liposomes with or without cholesterol to determine the mechanism of action of a biodetergent isolated from a cyanobacterium.Graphical

Complete publication list:

Research papers:

  1. Viktorsson EÖ, Melling Grøthe B, Aesoy R, Sabir M, Snellingen S, Prandina A, Høgmoen Åstrand OA, Bonge-Hansen T, Døskeland SO, Herfindal L, Rongved P. Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. Bioorg Med Chem. 2017 25(7), 2285-2293
  2. Vu M, Herfindal L, Juvik OJ, Vedeler A, Haavik S, Fossen T (2016). Toxic aromatic compounds from fruits of Narthecium ossifragum L. Phytochemistry 132, 76-85. (doi: 10.1016/j.phytochem.2016.09.010)
  3. Humisto A, Herfindal L, Jokela J, Bjørnstad R, Choudhury R, Sivonen K (2016). Cyanobacteria as a Source for Novel Anti-Leukemic Compounds. Curr Pharm Biotechnol 17(1), 78-91
  4. Evensen L, Johansen PL, Koster G, Zhu K, Herfindal L, Speth M, Fam SB, Fenaroli F, Prasmickaite L, Mælandsmo G, Snaar-Jagalska E, Griffiths G (2016). Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale 8(2), 862-77 (doi: 10.1039/c5nr07289a)
  5. Giraud F, Bourhis M, Ebrahimi E, Herfindal L, Døskeland SO, Anizon F, Moreau P (2015). Synthesis and biological activities of diversely substituted N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes. Eur J Med Chem 23(22), 7313-23
  6. Bouaziz Z, Issa S, Gentili J, Gratz A, Bollacke A, Kassack M, Jose J, Herfindal L, Gausdal G, Doskeland SO, Mullié C, Sonnet P, Desgrouas C, Taudon N, Valdameri G, Di Pietro A, Baitiche M, Le Borgne M (2015): Biologically active carbazole derivatives: Focus on oxazinocarbazoles and related compounds. J Enz Inhib Med Chem 30(2), 180-8.
  7. Giraud F, Bourhis M, Herfindal L, Døskeland SO, Anizon F, Moreau P (2014). New N-1/N-10 bridged pyrrolo[2,3-α]carbazole-3-carbaldehydes as Pim kinase modulators: Effect of the bridge on the kinase inhibitory potency. Bioorg Chem (doi: 10.1016/j.bioorg.2014.09.004).
  8. Liu L, Jokela J, Herfindal L, Wahlsten M, Sinkkonen J, Permi P, Fewer D, Døskeland SO, Sivonen K (2014). 4-methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides. ACS Chem Biol (doi: 10.1021/cb500436p).
  9. Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Døskeland SO, Kleppe R, Selheim F (2014): Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression. Biochem Biophys Res Commun 449(3), 357-363.
  10. Myhren L, Nilssen I, Nicolas V, Døskeland SO, Barrat G, Herfindal L (2014): Multi-functional liposomes containing daunorubicin and emetine against acute myeloid leukemia. Eur J Pharm Biopharm 88(1):186-93.
  11. Liu L, Herfindal L, Jokela J, Shishido T, Wahlsten M, Døskeland SO, Sivonen K (2014): Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells. Mar Drugs 14(4), 2036-2053.
  12. Herfindal L, Krakstad C, Myhren L, Hagland H, Kleppe R, Døskeland SO (2014): Increasing number of ring-containing substituents in cyclic nucleotides is associated with inhibition of the hepatocyte transporters OATP 1B1 and 1B3. PLoSONE 9(4):e94926.
  13. Bouaziz Z, Issa S, Gentili J, Gratz A, Bollacke A, Kassack M, Jose J, Herfindal L, Gausdal G, Doskeland SO, Mullié C, Sonnet P, Desgrouas C, Taudon N, Valdameri G, Di Pietro A, Baitiche M, Le Borgne M (2014): Biologically active carbazole derivatives: Focus on oxazinocarbazoles and related compounds. J Enz Inhib Med Chem (doi:10.3109/14756366.2014.899594).
  14. Prestegard S, Knutsen G, Herfindal L (2014): Adenosine levels and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): Effect of light, temperature, salinity and nitrate. Diatom Res 29(4), 361-369.
  15. Sletta H, Degnes KF, Herfindal L, Klinkenberg G, Fjærvik E, Zahlsen K, Brunsvik A, Nygaard G, Aachmann FL, Ellingsen TE, Døskeland SO, Zotchev SB (2014): Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment. Appl Microbiol Biotechnol 98(2):603-10.
  16. Herfindal L, Nygaard G, Kopperud R, Krakstad C, Døskeland SO, Selheim F (2013): Off-target effect of the Epac agonist 8-pCPT-2′-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun 437(4), 603–608.
  17. Herfindal L, Gjertsen BT, Døskeland SO, Gausdal G (2013) Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. BMC Cancer 13:341. doi: 10.1186/1471-2407-13-341.
  18. Myhren L, Nygaard G, Gausdal G, Teigen K, Sletta H, Selheim F, Bruserud Ø, Døskeland SO, Herfindal L (2013): Iodinin (1,6-dihydroxyphenazine 5,10 dioxide) is a potent anti-leukemic compound with high selectivity towards AML cell lines and patient blasts. Marine Drugs 11(2), 332-349.
  19. Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Herfindal L, Kleppe R, Rouhee N, McCormack E, Havemann U, Schwede F, Bruserud Ø, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO (2013): Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. Cell Death Dis 4: e516; doi:10.1038/cddis.2013.39.
  20. Oftedal L, Myhren L, Jokela J, Gausdal G, Sivonen K, Døskeland SO, Herfindal L (2012): The lipopeptide toxins Anabaenolysin A and B target biological membranes in a cholesterol-dependent manner. BBA Biomembranes 1818(12):3000-9.
  21. Jokela J, Oftedal L, Herfindal L, Permi P, Wahlsten M, Døskeland SO, Sivonen K (2012): Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria. PLoS ONE 7(7) e41222.
  22. Herfindal L, Myhren L, KleppeR, Krakstad C, Selheim F, Jokela J, Sivonen K, DøskelandSO (2011): Ncp-M1: A potent, nontoxic inhibitor of the hepatocyte transporters OATP1B3 and 1B1. Mol Pharm 8(2):360-7.
  23. Oftedal L, Skjærven KH, Coyne RT, Edvardsen B, Rohrlack T, Skulberg OM, Døskeland SO, Herfindal L (2011): The apoptosis inducing activity towards leukaemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse-bioassay toxicity. J Industrial Microbiol Biotechnol 38(4):489-501.
  24. Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO Herfindal L (2010): Compounds from benthic cyanobacteria synergise with daunorubicin to induce apoptosis in leukaemia cells, but not in normal cardiomyoblasts. Mar Drugs 8(10):2659-72.
  25. Jokela J, Herfindal L, Wahlsten M, Permi P, Selheim F, Vasconcelos V, Døskeland SO, Sivonen K (2010): A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystin. Chembiochem 11(11):1594-9.
  26. Prestegard SK, Oftedal L, Coyne RT, Nygaard G, Skjaerven KH, Knutsen G, Døskeland SO, Herfindal L (2009): Marine benthic diatoms contain compounds able to induce leukemia cell death and modulate blood platelet activity. Mar Drugs 7(4):605-23.
  27. Jørgensen H, Degnes KF, Sletta H, Fjaervik E, Dikiy A, Herfindal L, Bruheim P, Klinkenberg G, Bredholt H, Nygård G, Døskeland SO, Ellingsen TE, Zotchev SB (2009): Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chem Biol 16(10):1109-21.
  28. Herfindal L, Kasprzykowski F, Schwede F, Łankiewicz L, Fladmark KE, Łukomska J, Wahlsten M, Sivonen K, Grzonka Z, Jastorff B, Døskeland SO (2009): Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells. J Med Chem 52(18): 5758-62.
  29. Martins RF, Ramos MF, Herfindal L, Sousa JA, Skaerven K, Vasconcelos VM (2008): Antimicrobial and cytotoxic assessment of marine cyanobacteria – Synechocystis and Synechococcus. Mar Drugs. 6(1):1-11.
  30. Krakstad C, Herfindal L, Gjertsen BT, Bøe R, Fladmark KE, Døskeland SO (2006): CaM-kinaseII dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. Cell Death Differ 13:1191-1202.
  31. Selheim F, Herfindal L, Martins R, Vasconcelos V, Døskeland SO (2005): Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast. Aquatic Toxicol 74: 294-306.
  32. Herfindal L, Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO (2005): A high proportion of benthic Baltic Sea cyanobacterial isolates contain inducers of isolated rat hepatocyte apoptosis. Toxicon 46: 252-260.

Review articles and book chapters

  1. Selheim F, Herfindal L (2016). Editorial: Toward Personalized Treatment for Acute Myeloid Leukemia. Curr Pharm Biotechnol 17(1), 4-5
  2. Sauvage F, Barratt G, Herfindal L, Vergnaud-Gauduchon J (2016). The use of nanocarriers in acute myeloid leukaemia therapy: challenges and current status. Curr Pharm Biotechnol 17(1), 30-41
  3. Kleppe R, Herfindal L, Døskeland SO (2015). Cell Death Inducing Microbial Protein Phosphatase Inhibitors–Mechanisms of Action. Mar Drugs 13(10):6505-20.
  4. Kleppe R, Herfindal L, Madsen L, Haavik J, Selheim F, Døskeland SO (2015): Cyclic AMP and cGMP recognition and selectivity – guidelines for the use of cAMP analogs. In Xiaodong Cheng (ed): Cyclic Nucleotide Signaling. CRC Press, Taylor and Francis.
  5. Herfindal L, Selheim F (2006): Microcystin produces disparate effects on liver cells in a dose dependent manner. Mini Rev Med Chem 6: 279-285.
  6. Gausdal G, Krakstad C, Herfindal L, Døskeland SO (2006): Serine/Threonine phosphatases and apoptosis. In Rakesh Srivastava (ed): Apoptosis, Cell Signaling, and Human Disease: Molecular Mechanisms. The Human Press, Inc.
  7. Bruserud Ø, Glenjen N, Gjertsen BT, Herfindal L, Døskeland SO (2002): Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells. Exp Opin Biol Ther 2:197-210.

 

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